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He подавляет киназу II - фермент, разрушающий брадикинин. Снижает ОПСС, концентрацию в крови адреналина и альдостерона, АД, давление в малом круге кровообращения. Уменьшает постнагрузку, оказывает диуретический эффект. Препятствует развитию гипертрофии миокарда, повышает толерантность к физической нагрузке у пациентов с сердечной недостаточностью.\n\nПосле однократного приема гипотензивное действие (уменьшается систолическое и диастолическое АД) достигает максимума через 6 ч, затем в течение 24 ч постепенно снижается.\n\nМаксимальный гипотензивный эффект достигается через 3-6 недель после начала приема препарата.\n\n##### ФАРМАКОКИНЕТИКА\n\n _Всасывание_\n\nЛозартан быстро абсорбируется из ЖКТ. Биодоступность - около 33%. Тmax лозартана достигается через 1 ч.\n\n_Метаболизм_\n\nПодвергается эффекту \"первого прохождения\" через печень, метаболизируется путем карбоксилирования при участии изофермента CYP2С9 с образованием активного метаболита. Тmax активного метаболита достигается через 3-4 ч. Связывание с белками плазмы крови - 99%.\n\n_Выведение_\n\nT1/2 лозартана составляет 1.5-2 ч, а его основного метаболита - 6-9 ч. Около 35% дозы выводится с мочой, около 60% - через кишечник.\n\n_Фармакокинетика в особых клинических случаях_\n\nУстановлено, что концентрация лозартана в плазме крови у больных циррозом печени значительно увеличивается.\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * артериальная гипертензия;\n * хроническая сердечная недостаточность (в составе комбинированной терапии, при непереносимости или неэффективности терапии ингибиторами АПФ).\n\n\n\n##### МКБ-10\n\nКод МКБ-10| Показание \n---|--- \nI10| Эссенциальная [первичная] гипертензия \nI50.0| Застойная сердечная недостаточность \n \n##### ПРОТИВОПОКАЗАНИЯ\n\n * артериальная гипотензия;\n * гиперкалиемия;\n * дегидратация;\n * беременность;\n * период лактации (грудного вскармливания);\n * возраст до 18 лет (эффективность и безопасность не установлены);\n * повышенная чувствительность к компонентам препарата.\n\n\n\nС _осторожностью_ следует назначать препарат при печеночной недостаточности.\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nДанных по применению лозартана при беременности нет. Однако известно, что препараты, воздействующие непосредственно на ренин-ангиотензиновую систему, при применении во II и III триместрах беременности, могут вызывать дефект развития или даже смерть развивающегося плода. Поэтому при возникновении беременности прием Вазотенза следует немедленно прекратить.\n\nПри назначении в период лактации следует принять решение о прекращении грудного вскармливания или о прекращении лечения Вазотензом.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nПротивопоказание: возраст до 18 лет (эффективность и безопасность не установлены). \n\n##### ПРИМЕНЕНИЯ ПРИ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ\n\n**Пациентам с нарушениями функции печени (в т.ч. с циррозом печени)** следует назначать более низкие дозы Вазотенза. \n\nУ **больных с нарушениями функции почек, включая пациентов на диализе,** нет необходимости в коррекции начальной дозы. \n\nУ **пациентов пожилого возраста** нет необходимости в коррекции начальной дозы. \n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nПрепарат принимают внутрь, вне зависимости от приема пищи, кратность приема - 1 раз/сут.\n\nПри _артериальной гипертензии_ средняя суточная доза составляет 50 мг. В отдельных случаях для достижения большего эффекта дозу увеличивают до 100 мг в 2 приема или 1 раз/сут.\n\nПри назначении препарата пациентам, получающим диуретики в высоких дозах, начальную дозу препарата Вазотенз следует снизить до 25 мг 1 раз/сут.\n\nНачальная доза для пациентов с _сердечной недостаточностью_ составляет 12.5 мг 1 раз/сут. Как правило, доза увеличивается с недельным интервалом (т.е. 12.5 мг/сут, 25 мг/сут и 50 мг/сут) до средней поддерживающей дозы 50 мг 1 раз/сут в зависимости от переносимости препарата пациентом.\n\n**Пациентам с нарушениями функции печени (в т.ч. с циррозом печени)** следует назначать более низкие дозы Вазотенза. \n\nУ **пациентов пожилого возраста, а также у больных с нарушениями функции почек, включая пациентов находящихся на диализе,** нет необходимости в коррекции начальной дозы.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\n _Со стороны ЦНС и периферической нервной системы:_ ≥1% - головокружение, астения, головная боль, утомляемость, бессонница; <1% - беспокойство, нарушение сна, сонливость, расстройства памяти, периферическая невропатия, парестезии, гипостезии, мигрень, тремор, атаксия, депрессия, синкопе.\n\n_Со стороны органов чувств:_ звон вушах, нарушение вкуса, изменение зрения, конъюнктивит.\n\n_Со стороны дыхательной системы:_ ≥1%- заложенность носа, кашель*, инфекции верхних дыхательных путей (повышенная температура тела, боль в горле, синусопатия*, синусит, фарингит); <1% - диспноэ, бронхит, ринит.\n\n_Со стороны пищеварительной системы:_ ≥1% - тошнота, диарея*, диспептические явления*, боль в животе; <1% - анорексия, сухость во рту, зубная боль, рвота, метеоризм, гастрит, запор.\n\n_Со стороны костно-мышечной системы:_ ≥1% - судороги, миалгия*, боль в спине, грудной клетке, ногах; <1% - артралгия, боль в плече, колене, артрит, фибромиалгия.\n\n_Со стороны сердечно-сосудистой системы:_ ортостатическая гипотензия (дозозависимая), сердцебиение, тахи- или брадикардия, аритмии, стенокардия.\n\n_Со стороны мочеполовой системы:_ <1% _-_ императивные позывы на мочеиспускание, инфекции мочевыводящих путей, нарушение функции почек, ослабление либидо, импотенция.\n\n_Дерматологические реакции:_ <1% - сухость кожи, эритема, приливы крови, фотосенсибилизация, повышенное потоотделение, алопеция.\n\n_Аллергические реакции:_ <1% - крапивница, сыпь, зуд, ангионевротический отек (в т.ч. лица, губ, глотки и/или языка).\n\n_Прочие:_ гиперкалиемия (калий сыворотки более 5.5 ммоль/л), анемия.\n\n* Отмечены побочные эффекты, частота развития которых сопоставима с плацебо.\n\nСвязь побочных эффектов, встречающихся с частотой <1% случаев, с применением лозартана не доказана.\n\nВ большинстве случаев Вазотенз хорошо переносится, побочные эффекты носят преходящий характер и не требуют отмены препарата.\n\n##### ПЕРЕДОЗИРОВКА\n\n _Симптомы:_ выраженное снижение АД, тахикардия, из-за парасимпатической (вагусной) стимуляции может появляться брадикардия.\n\n_Лечение:_ форсированный диурез, симптоматическая терапия; гемодиализ неэффективен.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nНе отмечено клинически значимого взаимодействия с гидрохлоротиазидом, дигоксином, непрямыми антикоагулянтами, циметидином, фенобарбиталом.\n\nУ пациентов с дегидратацией (предшествовавшее лечение диуретиками в высоких дозах) может возникать выраженное снижение АД.\n\nУсиливает (взаимно) эффект других гипотензивных средств (мочегонных, бета-адреноблокаторов, симпатолитиков).\n\nПовышает риск гиперкалиемии при совместном применении с калийсберегающими диуретиками и препаратами калия.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nНеобходимо проводить коррекцию дегидратации до назначения препарата Вазотенз или начинать лечение с применения препарата в более низкой дозе.\n\nПрепараты, оказывающие воздействие на ренин-ангиотензиновую систему, могут увеличивать концентрацию мочевины в крови и сывороточного креатинина у пациентов с билатеральным почечным стенозом или стенозом артерии единственной почки.\n\nВ период лечения следует регулярно контролировать концентрацию калия в крови, особенно у пациентов пожилого возраста, при нарушениях функции почек.\n\nПрепарат может назначаться с другими гипотензивными средствами.\n\n_Использование в педиатрии_\n\nБезопасность и эффективность применения препарата у детей не установлены.\n\n##### СРОК ГОДНОСТИ\n\nСрок годности - 2 года. \n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПрепарат следует хранить в недоступном для детей месте при температуре не выше 30°С. \n\n##### УСЛОВИЯ ОТПУСКА\n\nПо рецепту\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * артериальная гипотензия;\n * гиперкалиемия;\n * дегидратация;\n * беременность;\n * период лактации (грудного вскармливания);\n * возраст до 18 лет (эффективность и безопасность не установлены);\n * повышенная чувствительность к компонентам препарата.\n\n\n\nС _осторожностью_ следует назначать препарат при печеночной недостаточности.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1113],{"_1114":1115,"_274":1116},"details","Цена действительна только при заказе онлайн. 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ЛОЗАРТАН-КСАНТИС ТАБ П/П/О 50МГ №60

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