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ФОРМА\n\nМазь глазная\n\n##### СОСТАВ\n\nВ 1 г мази содержатся:\n\n_Действующее вещество:_ ципрофлоксацина гидрохлорид (в пересчете на ципрофлоксацин - 3,00 мг) - 3,49 мг.\n\n_Вспомогательные вещества:_ метилпарагидроксибензоат (нипагин), вазелин, ланолин безводный.\n\n##### ОПИСАНИЕ\n\nОднородная мазь белого или белого со слегка желтоватым, зеленоватым или сероватым оттенком цвета.\n\n##### ФАРМАКО-ТЕРАПЕВТИЧЕСКАЯ ГРУППА\n\nСредства, применяемые в офтальмологии; противомикробные средства; фторхинолоны\n\n##### КОД АТХ\n\nS01AE03 - Ципрофлоксацин\n\n##### ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА\n\n** _Фармакодинамика_**\n\nПротивомикробное средство широкого спектра действия, производное фторхинолона, подавляет бактериальную ДНК-гиразу (топоизомеры II и IV, ответственные за раскручивание ДНК для обеспечения дальнейшего процесса транскрипции), нарушает синтез ДНК, рост и деление бактерий.\n\nДействует бактерицидно на грамотрицательные организмы в период покоя и деления, на грамположительные - только в период деления.\n\nК ципрофлоксацину чувствительны грамотрицательные аэробные бактерии: энтеробактерии (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp.), другие грамотрицательные бактерии (Haemophilus spp., Pseudomonas aeruginosa, Moraxella eatarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), некоторые внутриклеточные возбудители (Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae); грамположительные аэробные бактерии: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).\n\nБольшинство стафилококков, устойчивых к метициллину, резистентны и к ципрофлоксацину. Чувствительность Streptococcus pneumoniae, Enterococcus faecalis, Mycobacterium avium (расположенных внутриклеточно) - умеренная (для их подавления требуются высокие концентрации).\n\nК препарату резистентны: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Неэффективен в отношении Treponema pallidum.\n\nРезистентность развивается крайне медленно, поскольку с одной стороны, после действия ципрофлоксацина практически не остается персистирующих микроорганизмов, а с другой - у бактериальных клеток нет ферментов, инактивирующих его.\n\n**_Фармакокинетика_**\n\nПри местном применении системная абсорбция низкая.\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * Инфекционно-воспалительные заболевания глаз, вызванные чувствительными микроорганизмами (острый и подострый конъюнктивит, блефарит, блефароконъюнктивит, кератит, кератоконъюнктивит, бактериальная язва роговицы, хронический дакриоцистит, мейбомит, инфекционные поражения глаз после травм или попадания инородных тел);\n * пред- и послеоперационная профилактика инфекционных осложнений в офтальмо хирургии.\n\n\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * Гиперчувствительность к ципрофлоксацину или другим хинолонам, или к любому из вспомогательных веществ;\n * беременность;\n * период грудного вскармливания;\n * детский возраст (до 2-х лет);\n * вирусные и грибковые поражения глаз.\n\n\n\n##### МЕРЫ ПРЕДОСТОРОЖНОСТИ\n\n**С осторожностью**\n\nПрименять с осторожностью пациентам с атеросклерозом сосудов головного мозга, нарушением мозгового кровообращения, судорожным синдромом.\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nПрепарат противопоказан при беременности и в период грудного вскармливания.\n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nВзрослым и детям старше 2 лет полоску мази длиной 1-1,5 см закладывают за нижнее веко пораженного глаза 3 раза в день в течение 2-х суток. Затем в течение 5 дней применяют препарат 2 раза в день. В случае развития тяжелого инфекционного процесса мазь закладывается каждые 3-4 часа, по мере уменьшения явлений воспаления, уменьшают частоту применения препарата.\n\nКурс лечения не должен превышать 14 дней. Для введения мази следует осторожно оттянуть нижнее веко вниз и, слегка нажав на тюбик, ввести в конъюнктивальный мешок полоску мази. Затем медленно отпустить веко и прижать его с помощью ватной палочки или ватного тампона в течение 1-2 минут. После этого следует закрыть глаза на 1-2 минуты.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nСреди нежелательных реакций в клинических исследованиях наиболее часто отмечали нарушения со стороны органа зрения: точечный поверхностный кератит, отложение преципитатов и раздражение глаз.\n\nКлассификация частоты возникновения нежелательных реакций согласно рекомендациям ВОЗ: очень часто: ≥1/10; часто: от ≥1/100 до <1/10; нечасто: от ≥1/1000 до <1/100; редко: от ≥1/10000 до <1/1000; очень редко: <1/10000, частота неизвестна: невозможно оценить на основании имеющихся данных.\n\n**Таблица 1.** Нежелательные лекарственные реакции при применении препарата Офтоципро (ципрофлоксацин).\n\nСистемноорганный класс| очень часто: ≥1/10| часто: от≥1/100 до <1/10| нечасто: от ≥1/1000 до <1/100| редко: от≥1/10000 до <1/1000| очень редко: <1/10000| частота неизвестна: невозможно оценить на основании имеющихся данных. \n---|---|---|---|---|---|--- \nСо стороны иммунной системы| | | | аллергические реакции| | \nСо стороны органа зрения| | зуд, жжение, легкая болезненность и конъюнктивальная инъекция| | отек век, светобоязнь, слезотечение, ощущение инородного тела в глазах, появление белого кристаллиеского преципитата у больных с язвой роговицы, кератин, кератопатия, инфильтрация роговицы, снижение остроты зрения, развитие суперинфекции| | \nСо стороны желудочно-кишечного тракта| | | | неприятный привкус во рту сразу после закладывания| | тошнота \n \nДети\n\nИсследования офтальмологических растворов, содержащих ципрофлоксацин не выявили никаких серьезных нежелательных реакций у детей.\n\nИсследование препарата Офтоципро у пациентов возрастом от 2 до 7 лет с кератитом также показала хорошую переносимость препарата у детей.\n\n##### ПЕРЕДОЗИРОВКА\n\n _Симптомы:_ данные по передозировке препарата отсутствуют. При случайном приеме препарата внутрь специфические симптомы отсутствуют. Возможно возникновение тошноты, рвоты, диареи, головной боли, обморока, чувства тревоги.\n\n_Лечение:_ стандартные меры неотложной помощи, достаточное поступление жидкости в организм, создание кислой реакции мочи для предотвращения кристаллурии.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nВзаимодействие Офтоципро® с другими препаратами при одновременном применении не выявлено.\n\nИмеются сведения, что системное применение некоторых хинолонов приводит к повышению концентрации теофиллина в плазме крови, влияет на метаболизм кофеина и усиливает действие пероральных антикоагулянтов (в т.ч. варфарин и его производные). Сообщалось о временном повышении уровня креатинина в сыворотке крови у пациентов, которым назначали циклоспорин вместе с системным применением ципрофлоксацина.\n\n##### ФОРМА ВЫПУСКА\n\nМазь глазная 0,3 %.\n\nПо 3 г, 5 г или 10 г в тубы алюминиевые.\n\nПо 3 г, 5 г или 10 г в тубы ламинатные.\n\nТубу вместе с инструкцией по медицинскому применению помещают в пачку из картона.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nВ период лечения препаратом не рекомендуется ношение контактных линз.\n\nВ случае совместного применения с другими местными офтальмологическими препаратами интервал между их применением должен составлять не менее 5 минут, при этом глазные мази необходимо применять в последнюю очередь.\n\n##### ВЛИЯНИЕ НА УПРАВЛЕНИЕ ТРАНСПОРТНЫМИ СРЕДСТВАМИ И МЕХАНИЗМАМИ\n\nСразу после использования глазной мази возможна нечеткость зрительного восприятия, что может повлечь затруднение при управлении транспортными средствами и при работе требующей повышенного внимания и быстроты психомоторных реакций. Рекомендуется приступать к работе (вождению) через 15 минут после применения препарата.\n\n##### СРОК ГОДНОСТИ\n\n3 года.\n\nХранить после первого вскрытия упаковки не более 6 недель.\n\nНе применять по истечении срока годности.\n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПри температуре не выше 25 °С.\n\nХранить в недоступном для детей месте.\n\n##### УСЛОВИЯ ОТПУСКА\n\nПо рецепту\n\n##### ПРОИЗВОДИТЕЛЬ И ПРИНИМАЮЩИЙ ПРЕТЕНЗИИ\n\n**Производитель**\n\nАО \"Татхимфармпрепараты\", Россия\n\nРеспублика Татарстан, г. Казань, ул. Беломорская, д. 260\n\nтел.: 8 800 201 98 88,\n\nтел./факс: +7 (843) 571-85-58\n\ne-mail: marketing@tatpharm.ru\n\n**Владелец регистрационного удостоверения/Организация, принимающая претензии от потребителей**\n\nАО \"Татхимфармпрепараты\", Россия\n\n420091, Республика Татарстан, г. Казань, ул. Беломорская, д. 260\n\nтел.: 8 800 201 98 88,\n\nтел./факс: +7 (843) 571-85-58\n\ne-mail: marketing@tatpharm.ru\n\n##### СОСТАВ\n\nВ 1 г мази содержатся:\n\n_Действующее вещество:_ ципрофлоксацина гидрохлорид (в пересчете на ципрофлоксацин - 3,00 мг) - 3,49 мг.\n\n_Вспомогательные вещества:_ метилпарагидроксибензоат (нипагин), вазелин, ланолин безводный.\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * Гиперчувствительность к ципрофлоксацину или другим хинолонам, или к любому из вспомогательных веществ;\n * беременность;\n * период грудного вскармливания;\n * детский возраст (до 2-х лет);\n * вирусные и грибковые поражения глаз.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1114],{"_1115":1116,"_274":1117},"details","Цена действительна только при заказе онлайн. 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