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ФАРМАКО-ТЕРАПЕВТИЧЕСКАЯ ГРУППА\n\nПротивогрибковое средство\n\n##### ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА\n\nПротивогрибковый препарат для наружного применения. Оказывает фунгистатическое и фунгицидное действие, обусловленное повреждением цитоплазматической мембраны гриба путем нарушения биосинтеза стеролов. Снижается содержание эргостерола, накапливается содержание атипичных стерических неплоских стеролов.\n\nОбладает широким спектром противогрибкового действия. Высокоактивен в отношении как наиболее распространенных, так и редких возбудителей грибковых поражений ногтей:\n\n * дерматофитов - Trichophyton spp., Microsporum spp., Epidermophyton spp.;\n * дрожжевых грибов - Candida spp., Cryptococcus spp., Malassezia spp. (Pityrosporum spp.);\n * плесневых грибов - Alternaria spp., Scopulariopsis spp., Hendersonula spp.;\n * грибов из семейства Dematiaceae - Cladopsorium spp., Fonsecaea spp., Wangiella spp.;\n * диморфных грибов - Coccidioides spp., Histoplasma spp., Sporothrix spp.\n\n\n\n##### ФАРМАКОКИНЕТИКА\n\nПри нанесении на ногти проникает в ногтевую пластинку и далее в ногтевое ложе (практически полностью в течение первых 24 ч). Эффективная концентрация сохраняется в пораженной ногтевой пластинке в течение 7-10 дней уже после первой аппликации. Системная абсорбция незначительна: концентрация в плазме находится ниже предела чувствительности методов определения (менее 0.5 нг/мл).\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * лечение грибковых поражений ногтей, вызванных дерматофитами, дрожжевыми и плесневыми грибами;\n * профилактика грибковых поражений ногтей.\n\n\n\n##### МКБ-10\n\nКод МКБ-10| Показание \n---|--- \nB35.1| Микоз ногтей \nB37.2| Кандидоз кожи и ногтей \n \n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к аморолфину или любому из компонентов препарата.\n\n\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nДанные о применении аморолфина при беременности и/или в период грудного вскармливания ограничены. Исследования на животных показали наличие репродуктивной токсичности при пероральном применении препарата в высоких дозах. Ввиду крайне низкого системного воздействия аморолфина при его наружном применении в форме лака для ногтей степень риска для плода незначительна. Неизвестно, проникает ли аморолфин в грудное молоко.\n\nВвиду ограниченности данных о применении аморолфина у беременных и кормящих женщин, применение препарата при беременности и в период грудного вскармливания не рекомендуется.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nКлинические данные о применении препарата у пациентов детского возраста отсутствуют, поэтому не следует назначать Лоцерил® детям.\n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nНаружно. Наносить на пораженные ногти пальцев рук или ног 1-2 раза в неделю следующим образом:\n\n1\\. До применения препарата удалить по возможности пораженные участки ногтя (особенно с его поверхности) с помощью прилагаемой пилки для ногтей.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_e2edcfe82d.jpg)\n\n2\\. Затем поверхность ногтя очистить и обезжирить прилагаемым тампоном, смоченным спиртом.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_8e07b95412.jpg)\n\nПеред каждым последующим применением препарата необходимо также проводить обработку пораженных ногтей пилкой и затем удалять оставшийся слой лака спиртовым тампоном.\n\n3\\. Опустить встроенный в крышку аппликатор во флакон с лаком и затем аккуратно вынуть его, не стирая излишки лака о горлышко флакона.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_e1dcc6f466.jpg)\n\n4\\. С помощью аппликатора нанести лак ровным слоем на всю поверхность пораженного ногтя.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_f29942f914.jpg)\n\nВышеописанную процедуру повторить для каждого пораженного ногтя.\n\n5\\. Дать лаку высохнуть в течение 3 мин.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_09b09baf85.jpg)\n\n6\\. Протереть аппликатор тампоном, использованным для очистки ногтя, избегая при этом контакта обработанных ногтей и тампона. Плотно закрыть флакон сразу же по окончании процедуры. Использованный тампон выбросить.\n\n![](https://cdn.pharm-portal.ru/kk44ezuyq8bt3pjxdartuarh/instruction_image_ec43dc79b2.jpg)\n\nНанесение декоративного лака для ногтей возможно не ранее чем через 10 мин после применения лака для ногтей Лоцерил®.\n\nПри повторном применении лака Лоцерил® необходимо аккуратно удалить с ногтей оставшийся декоративный лак, затем с помощью прилагаемых пилок обработать пораженные участки ногтей и удалить оставшийся слой лака спиртовыми тампонами.\n\nПо окончании процедуры тщательно вымыть руки. В случае, если лак наносился на ногти на руках, следует дождаться сначала его полного высыхания.\n\nПосле высыхания лака разрешается регулярное мытье рук и ног с использованием мыла.\n\nЛечение следует продолжать до регенерации ногтя и полного излечения пораженного участка.\n\nСредняя длительность лечения составляет 6 месяцев для ногтей на руках и 9-12 месяцев для ногтей на ногах.\n\nВвиду медленного роста ногтевых пластин первые признаки улучшения могут стать заметными только после 2-3 месяцев применения препарата. При отсутствии признаков улучшения по истечении 3 месяцев рекомендуется проконсультироваться с врачом.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nПри применении препарата Лоцерил® нежелательные реакции отмечаются редко. Такие повреждения ногтей, как изменение цвета, разрушение ногтевых пластин, ломкость ногтей, могут быть следствием грибкового поражения ногтей.\n\nВсе нежелательные реакции, отмеченные при применении препарата Лоцерил®, представлены в таблице ниже в соответствии со следующими категориями частоты: очень часто (≥1/10), часто (≥1/100-<1/10), нечасто (≥1/1000-<1/100), редко (≥1/10000-<1/1000), очень редко (<1/10000), частота неизвестна (не может быть оценена на основании имеющихся данных).\n\nЧастота встречаемости| Нежелательные лекарственные реакции \n---|--- \nСо стороны иммунной системы \nчастота неизвестна*| реакции гиперчувствительности (системные аллергические реакции)* \nСо стороны кожи и подкожных тканей \nредко (≥1/10 000-<1/1000)| повреждение ногтей \nизменение цвета ногтей \nонихоклазия (ломкость ногтевой пластинки) \nонихорексис (хрупкость ногтевой пластинки) \nочень редко (<1/10 000)| ощущение жжения кожи \nчастота неизвестна*| эритема* \nзуд* \nконтактный дерматит* \nкрапивница* \nобразование волдырей* \n \n* Данные пострегистрационных наблюдений.\n\nЕсли любые из указанных побочных эффектов усугубляются или отмечаются любые другие побочные эффекты, следует немедленно сообщить об этом врачу.\n\n##### ПЕРЕДОЗИРОВКА\n\nПри наружном применении препарата развитие системных признаков передозировки не ожидается.\n\nЛечение: при случайном проглатывании препарата необходимо провести соответствующую симптоматическую терапию.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nНе установлено.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nПилки, использованные для обработки пораженных ногтей, не следует использовать для обработки здоровых ногтей.\n\nЛица, работающие с органическими растворителями, должны надевать непроницаемые перчатки для защиты ногтей, покрытых лаком.\n\nВо время лечения следует избегать использования накладных искусственных ногтей.\n\nПрепарат содержит этанол, поэтому слишком частое или неправильное его нанесение может привести к появлению раздражения или сухости кожи вокруг ногтя.\n\nНе следует наносить лак Лоцерил® на кожу вокруг ногтя.\n\nТампон содержит легко воспламеняющееся вещество.\n\nСледует избегать попадания лака в глаза, уши и на слизистые оболочки. При попадании лака в глаза необходимо немедленно промыть их водой.\n\nПациентам с состояниями, предрасполагающими к развитию грибковых поражений ногтей (нарушение периферического кровообращения, сахарный диабет, иммунодефициты), а также пациентам с дистрофией ногтя или разрушенной ногтевой пластинкой, псориазом или другими хроническими заболеваниями кожи следует обратиться к врачу.\n\nВ случае если разрушению или грибковому поражению подвержено более 2/3 ногтевой пластинки, необходимо также обратиться к врачу для назначения сопутствующей пероральной терапии.\n\nПри возникновении системных и местных аллергических реакций следует немедленно прекратить применение лака Лоцерил® и обратиться к врачу. Используя жидкость для снятия лака, необходимо удалить препарат с ногтей. Не следует наносить препарат повторно.\n\nИспользование в педиатрии\n\nКлинические данные о применении препарата у пациентов детского возраста отсутствуют, поэтому не следует назначать Лоцерил® детям.\n\nВлияние на способность к управлению транспортными средствами и механизмами\n\nПрепарат не оказывает влияния на способность к управлению транспортными средствами и работе с механизмами.\n\n##### СРОК ГОДНОСТИ\n\nСрок годности - 3 года. Не применять по истечении срока годности. \n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПрепарат следует хранить в недоступном для детей месте при температуре не выше 30°С. \n\n##### УСЛОВИЯ ОТПУСКА\n\nОтпускают без рецепта\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к аморолфину или любому из компонентов препарата.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1107],{"_1108":1109,"_274":1110},"details","Цена действительна только при заказе онлайн. 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