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МНН / ГРУППИРОВОЧНОЕ НАИМЕНОВАНИЕ / ХИМИЧЕСКОЕ НАИМЕНОВАНИЕ\n\nДезлоратадин\n\n##### ЛЕК. ФОРМА\n\nТаблетки, покрытые пленочной оболочкой\n\n##### СОСТАВ\n\n1 таблетка содержит:\n\n_действующее вещество:_ дезлоратадин - 5,0 мг;\n\n_вспомогательные вещества:_ кальция гидрофосфата дигидрат, силикатированная микрокристаллическая целлюлоза, гипромеллоза (гидроксипропилметилцеллюлоза), кроскармеллоза натрия, кремния диоксид коллоидный (аэросил), магния стеарат;\n\n_состав оболочки:_ готовая смесь для пленочной оболочки голубая [поливиниловый спирт, титана диоксид (Е171), тальк (Е553b), макрогол (полиэтиленгликоль) (Е1521), алюминиевый лак на основе индигокармина (Е132)], эмульсия симетикона 30 % [вода, диметикон (полидиметилсилоксан), макрогол (полиэтиленгликоль) сорбитан тристеарат, метилцеллюлоза, силикагель].\n\n##### ОПИСАНИЕ\n\nКруглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, голубого цвета. Допустима незначительная шероховатость поверхности. Цвет таблеток на изломе - белый или белый с желтоватым или розоватым оттенком.\n\n##### ФАРМАКО-ТЕРАПЕВТИЧЕСКАЯ ГРУППА\n\nАнтигистаминные средства системного действия; другие антигистаминные средства системного действия\n\n##### КОД АТХ\n\nR06AX27 - Дезлоратадин\n\n##### ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА\n\n _Фармакодинамика_\n\nАнтигистаминный препарат длительного действия. Является первичным активным метаболитом лоратадина. Ингибирует каскад реакций аллергического воспаления, в том числе высвобождение провоспалительных цитокинов, включая интерлейкины ИЛ-4, ИЛ-6, ИЛ-8, ИЛ-13, высвобождение провоспалительных хемокинов (RANTES), продукцию супероксидных анионов активированными полиморфноядерными нейтрофилами, адгезию и хемотаксис эозинофилов, выделение молекул адгезии, таких как Р-селектин, IgE -опосредованное высвобождение гистамина, простагландина D2 и лейкотриена С4. Таким образом, предупреждает развитие и облегчает течение аллергических реакций, обладает противозудным и противоэкссудативным действием, уменьшает проницаемость капилляров, предупреждает развитие отека тканей, спазма гладкой мускулатуры.\n\nПрепарат не оказывает воздействия на центральную нервную систему, практически не обладает седативным эффектом (не вызывает сонливости) и не влияет на скорость психомоторных реакций. В клинико-фармакологических исследованиях применения дезлоратадина в рекомендуемой терапевтической дозе не отмечалось удлинения интервала QT на ЭКГ.\n\nДействие лекарственного препарата Дезлоратадин-АКОС начинается в течение 30 минут после приема внутрь и продолжается в течение 24 часов.\n\n \n\n\n_Фармакокинетика_\n\nДезлоратадин хорошо всасывается в желудочно-кишечном тракте. Определяется в плазме крови через 30 минут после приема внутрь. Максимальная концентрация достигается в среднем через 3 часа после приема. Не проникает через гематоэнцефалический барьер. Связь с белками плазмы составляет 83-87 %. При применении у взрослых и подростков в течение 14 дней в дозе от 5 мг до 20 мг 1 раз в сутки клинически значимой кумуляции препарата не отмечается.\n\nОдновременный прием пищи или грейпфрутового сока не влияет на распределение дезлоратадина при применении в дозе 7,5 мг 1 раз в день.\n\nДезлоратадин не является ингибитором CYP3A4 и CYP2D6 и не является субстратом или ингибитором Р-гликопротеина. Интенсивно метаболизируется в печени путем гидроксилирования с образованием 3-ОН-дезлоратадина, соединенного с глюкуронидом. Лишь небольшая часть принятой внутрь дозы выводится почками (< 2 %) и через кишечник (< 7 %). Период полувыведения - 20-30 часов (в среднем - 27 часов).\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * Повышенная чувствительность к дезлоратадину, лоратадину, а также к другим компонентам препарата;\n * беременность и период грудного вскармливания;\n * детский возраст до 12 лет.\n\n\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * Повышенная чувствительность к дезлоратадину, лоратадину, а также к другим компонентам препарата;\n * беременность и период грудного вскармливания;\n * детский возраст до 12 лет.\n\n\n\n##### МЕРЫ ПРЕДОСТОРОЖНОСТИ\n\n * Тяжелая почечная недостаточность;\n * судороги в анамнезе.\n\n\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nПрименение препарата при беременности противопоказано в связи с отсутствием клинических данных о безопасности применения дезлоратадина в данный период. Дезлоратадин выделяется с грудным молоком, поэтому его применение в период грудного вскармливания противопоказано.\n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nВнутрь, независимо от приема пищи. Препарат желательно принимать регулярно в одно и то же время суток. Таблетку следует проглатывать целиком, не разжевывая, запивая небольшим количеством воды.\n\n_Взрослым и подросткам от 12 лет_ \\- по 1 таблетке (5 мг) 1 раз в сутки.\n\nПри сезонном аллергическом рините (при наличии симптомов продолжительностью менее 4 дней в неделю или менее 4 недель в году) необходимо оценивать течение заболевания. При исчезновении симптомов прием препарата следует прекратить, при повторном появлении симптомов прием препарата следует возобновить.\n\nПри круглогодичном аллергическом рините (при наличии симптомов продолжительностью более 4 дней в неделю или более 4 недель в году) препарат следует принимать в течение всего периода экспозиции аллергена.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nНаиболее часто встречающиеся побочные эффекты (от ≥ 1/100 до <1/10), частота которых была несколько выше, чем при приеме плацебо («пустышки»): повышенная утомляемость (1,2 %), сухость во рту (0,8 %) и головная боль (0,6 %).\n\nУ детей в возрасте 12-17 лет, по результатам клинических исследований, наиболее часто встречающимся побочным эффектом являлась головная боль (5,9 %), частота которой была не выше, чем при приеме плацебо (6,9 %).\n\nИнформация о побочных эффектах представлена по результатам клинических исследований и наблюдений пострегистрационного периода.\n\nПо данным всемирной организации здравоохранения (ВОЗ) побочные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥ 1/10); часто (от ≥ 1/100 до < 1/10); нечасто (от ≥ 1/1000 до < 1/100); редко (от ≥ 1/10000 до < 1/1000); очень редко (< 1/10000); частота неизвестна - по имеющимся данным установить частоту возникновения не представлялось возможным.\n\n_Со стороны психики:_ очень редко - галлюцинации; частота неизвестна - аномальное поведение, агрессия.\n\n_Со стороны нервной системы:_ часто - головная боль; очень редко - головокружение, сонливость, бессонница, психомоторная гиперактивность, судороги.\n\n_Со стороны печени и желчевыводящих путей:_ очень редко повышение активности\n\nферментов печени, повышение концентрации билирубина, гепатит; частота неизвестна - желтуха.\n\n_Со стороны пищеварительной системы:_ часто - сухость во рту; очень редко - боль в животе, тошнота, рвота, диспепсия, диарея, повышение аппетита.\n\n_Со стороны сердечно-сосудистой системы:_ очень редко - тахикардия, сердцебиение; частота неизвестна - удлинение интервала QT.\n\n_Со стороны опорно-двигательного аппарата:_ очень редко - миалгия.\n\n_Со стороны кожи и подкожных тканей:_ частота неизвестна - фотосенсибилизация.\n\n_Общие расстройства:_ часто - повышенная утомляемость; очень редко - анафилаксия, ангионевротический отек, одышка, зуд, сыпь, в том числе крапивница; частота неизвестна - астения.\n\n_Лабораторные и инструментальные данные:_ повышение массы тела.\n\nПострегистрационный период\n\nДети: частота неизвестна - удлинение интервала QT, аритмия, брадикардия, аномальное поведение, агрессия.\n\nЕсли любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.\n\n##### ПЕРЕДОЗИРОВКА\n\n _Симптомы._ Прием дозы, превышающей рекомендованную в 5 раз, не приводил к появлению каких-либо симптомов. В ходе клинических исследований ежедневное применение у взрослых и подростков дезлоратадина в дозе до 20 мг в течение 14 дней не сопровождалось статистически или клинически значимыми изменениями со стороны сердечно-сосудистой системы. В клинико-фармакологическом исследовании применение дезлоратадина в дозе 45 мг в сутки (в 9 раз выше рекомендуемой) в течение 10 дней не вызывало удлинения интервала QT и не сопровождалось появлением серьезных побочных эффектов.\n\n_Лечение._ При случайном приеме внутрь большого количества препарата необходимо незамедлительно обратиться к врачу. Рекомендуется промывание желудка, прием активированного угля; при необходимости - симптоматическая терапия. Дезлоратадин не выводится при гемодиализе, эффективность перитонеального диализа не установлена.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nНе выявлено клинически значимых взаимодействий в исследованиях при совместном применении с азитромицином, кетоконазолом, эритромицином, флуоксетином и циметидином.\n\nОдновременный прием пищи или употребление эффективность препарата.\n\nДезлоратадин не усиливает действие алкоголя на ЦНС. Тем не менее, во время пострегистрационного применения были зарегистрированы случаи непереносимости алкоголя и алкогольного опьянения. Поэтому дезлоратадин одновременно с алкоголем следует применять с осторожностью.\n\n##### ФОРМА ВЫПУСКА\n\nПо 7 или 10 таблеток в блистер.\n\nПо 1, 2, 3, 4 или 5 блистеров вместе с инструкцией по применению в пачку картонную.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nИсследований эффективности лекарственного препарата Дезлоратадин-АКОС при ринитах инфекционной этиологии не проводилось.\n\nНеобходимо соблюдать осторожность при применении препарата Дезлоратадин-АКОС у пациентов с судорогами в анамнезе, особенно у пациентов детского возраста. Следует прекратить применение препарата в случае развития судорог.\n\n##### ВЛИЯНИЕ НА УПРАВЛЕНИЕ ТРАНСПОРТНЫМИ СРЕДСТВАМИ И МЕХАНИЗМАМИ\n\nСледует принимать во внимание потенциальную возможность развития таких побочных эффектов, как головокружение и сонливость. При появлении описанных нежелательных явлений следует воздержаться от выполнения указанных видов деятельности.\n\n##### СРОК ГОДНОСТИ\n\n4 года.\n\nНе использовать после истечения срока годности.\n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nВ защищенном от света месте, при температуре не выше 25 °C.\n\nХранить в недоступном для детей месте.\n\n##### УСЛОВИЯ ОТПУСКА\n\nОтпускают без рецепта\n\n##### ПРОИЗВОДИТЕЛЬ И ПРИНИМАЮЩИЙ ПРЕТЕНЗИИ\n\nБИОКОМ АО\n\n##### СОСТАВ\n\n1 таблетка содержит:\n\n_действующее вещество:_ дезлоратадин - 5,0 мг;\n\n_вспомогательные вещества:_ кальция гидрофосфата дигидрат, силикатированная микрокристаллическая целлюлоза, гипромеллоза (гидроксипропилметилцеллюлоза), кроскармеллоза натрия, кремния диоксид коллоидный (аэросил), магния стеарат;\n\n_состав оболочки:_ готовая смесь для пленочной оболочки голубая [поливиниловый спирт, титана диоксид (Е171), тальк (Е553b), макрогол (полиэтиленгликоль) (Е1521), алюминиевый лак на основе индигокармина (Е132)], эмульсия симетикона 30 % [вода, диметикон (полидиметилсилоксан), макрогол (полиэтиленгликоль) сорбитан тристеарат, метилцеллюлоза, силикагель].\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * Повышенная чувствительность к дезлоратадину, лоратадину, а также к другим компонентам препарата;\n * беременность и период грудного вскармливания;\n * детский возраст до 12 лет.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1107],{"_1108":1109,"_274":1110},"details","Цена действительна только при заказе онлайн. 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ДЕЗЛОРАТАДИН ТАБ П/П/О 5МГ №10

МНН / ГРУППИРОВОЧНОЕ НАИМЕНОВАНИЕ / ХИМИЧЕСКОЕ НАИМЕНОВАНИЕ