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ФОРМА\n\nТаблетки.\n\n##### СОСТАВ\n\nВ одной таблетке содержится:\n\n_действующее вещество:_ морфолиний-метил- триазолил-тиоацетат (тиотриазолин) 200 мг;\n\n_вспомогательные вещества:_ крахмал картофельный 16 мг, повидон низкомолекулярный 8 мг, сахароза 5,6 мг, целлюлоза микрокристаллическая 8 мг, кальция стеарат 2,4 мг.\n\n##### ОПИСАНИЕ\n\nКруглые плоскоцилиндрические таблетки белого или почти белого цвета с фаской и риской.\n\n##### ФАРМАКО-ТЕРАПЕВТИЧЕСКАЯ ГРУППА\n\nАнтигипоксантное средство.\n\n##### КОД АТХ\n\nС01ЕВ\n\n##### ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА\n\n** _Фармакодинамика_**\n\nФармакологический эффект морфолиний-метил-триазолил-тиоацетата обусловлен противоишемическим, мембраностабилизирующим, антигипоксантным и иммуномодулирующим действием.\n\nВоздействие препарата реализуется за счет усиления компенсаторной активации анаэробного гликолиза и активации процессов окисления в цикле Кребса с сохранением внутриклеточного фонда аденозинтрифосфата. Наличие в структуре молекулы тиотриазолина тиола серы, для которой характерны окислительно-восстановительные свойства, и третичного азота, который связывает избыток ионов водорода, обуславливает активацию антиоксидантной системы. Восстановительные свойства тиольной группы вызывают реакцию с активными формами кислорода и липидными радикалами. Реактивация антирадикальных ферментов - супероксиддисмутазы, каталазы и глутатионпероксидазы - предотвращает инициацию активных форм кислорода.\n\nТиотриазолин® применяют при лечении заболеваний печени, учитывая его гепатопротекторные свойства. Препарат предотвращает разрушение гепатоцитов, снижает степень жировой инфильтрации и распространение центролобулярных некрозов печени, способствует процессам репаративной регенерации гепатоцитов, нормализует в них белковый, углеводный, липидный и пигментный обмены. Увеличивает скорость синтеза и выделения желчи, нормализует ее химический состав. Воздействие морфолиния-метил-триазолил-тиоацетата приводит к торможению процессов окисления липидов в ишемизированных участках миокарда, уменьшению чувствительности миокарда к катехоламинам, предотвращению прогрессивного угнетения сократительной функции сердца, стабилизации и уменьшению соответственно зоны некроза и ишемии миокарда. Улучшение реологических свойств крови осуществляется за счет активации фибринолитической системы. Улучшает процессы метаболизма в миокарде. Снижает количество приступов стенокардии и количество принятых таблеток нитроглицерина с целью купирования приступов стенокардии (по результатам клинического исследования).\n\n**_Фармакокинетика_**\n\nПосле приема внутрь морфолиний-метил- триазолил-тиоацетат быстро всасывается в желудочно-кишечном тракте, его абсолютная биодоступность составляет 53 %. Максимальная концентрация в плазме крови достигается через 1,6 ч после однократного приема внутрь в дозе 200 мг. Период полувыведения составляет почти 8 ч.\n\nМорфолиний-метил-триазолил-тиоацетат выводится преимущественно почками.\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\nТоксические поражения печени, в т.ч. алкогольного, вирусного и лекарственного происхождения (антибиотики, противоопухолевые, противотуберкулезные, противовирусные лекарственные средства, трициклические антидепрессанты, пероральные контрацептивы и т.д.). Хронический алкогольный гепатит минимальной и умеренной активности.\n\nХронический вирусный гепатит, жировая дистрофия печени, цирроз печени.\n\nИшемическая болезнь сердца: профилактика приступов стабильной стенокардии (в составе комбинированной терапии).\n\n##### ПРОТИВОПОКАЗАНИЯ\n\nПовышенная чувствительность к морфолиний-метил-триазолил-тиоацетату и другим вспомогательным компонентам препарата; умеренные и тяжелые нарушения функции почек (клиренс креатинина (КК) < 60 мл/мин); детский возраст до 18 лет (эффективность и безопасность не установлены). Беременность и период грудного вскармливания.\n\nДефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная мальабсорбция.\n\n##### МЕРЫ ПРЕДОСТОРОЖНОСТИ\n\n**С осторожностью:** сахарный диабет, нарушения функции почек (КК > 60 мл/мин) (опыт применения ограничен).\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nВ доклинических исследованиях тератогенный эффект не выявлен, однако в связи с отсутствием данных о применении препарата у беременных, назначение препарата Тиотриазолин® во время беременности не рекомендуется.\n\nНеизвестно, выделяется ли морфолиний-метил-триазолил-тиоацетат с грудным молоком. При необходимости применения препарата Тиотриазолин® в период лактации, грудное вскармливание необходимо прекратить.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nПротивопоказано детям до 18 лет (эффективность и безопасность не установлены).\n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nВнутрь. Не разжевывая, запивая водой.\n\n_Токсические поражения печени, хронический алкогольный гепатит:_ Тиотриазолин® назначают по 1 таблетке внутрь 3-4 раза в сутки.\n\n_Хронический вирусный гепатит, жировая дистрофия печени, цирроз печени: _Тиотриазолин® назначают по 1 таблетке внутрь 3-4 раза в сутки.\n\nКурс лечения 20-30 дней.\n\nМаксимальная суточная доза 800 мг.\n\n_Профилактика приступов стабильной стенокардии:_ Тиотриазолин® назначают по 1 таблетке внутрь 3 раза в сутки. Курс лечения -8 недель.\n\nРешение о повторном курсе лечения определяется врачом индивидуально, в зависимости от тяжести и особенностей течения заболевания.\n\n_Применение у пациентов с нарушениями функции почек_\n\nУ пациентов с легкими нарушениями функции почек (КК > 60 мл/мин) коррекции дозы не требуется. У пациентов с умеренными и тяжелыми нарушениями функции почек (КК < 60 мл/мин) применение препарата Тиотриазолин® противопоказано (см. раздел «Противопоказания»).\n\n_Применение в педиатрии_\n\nЭффективность и безопасность у детей до 18 лет не установлены.\n\n_Применение у пожилых пациентов (старше 65 лет)_\n\nКоррекции дозы не требуется.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nЧастота побочных реакций определялась в соответствии с рекомендациями Всемирной организации здравоохранения: очень часто (> 1/10); часто (> 1/100, < 1/10); нечасто (>1/1000, < 1/100; редко (> 1/10 000, < 1/1000); очень редко (< 1/10 000), включая отдельные сообщения; частота неизвестна (частота не может быть подсчитана по имеющимся данным).\n\n_Со стороны желудочно-кишечного тракта_ : очень редко - тошнота, сухость слизистой оболочки полости рта, вздутие живота.\n\n_Со стороны центральной и периферической нервной системы:_ очень редко - головокружение, шум в ушах.\n\n_Со стороны сердечно-сосудистой системы:_ очень редко - тахикардия, повышение артериального давления, боль в области сердца, аритмии.\n\n_Со стороны дыхательной системы:_ очень редко - одышка, бронхоспазм.\n\n_Аллергические реакции:_ очень редко - реакции повышенной чувствительности, ангионевротический отек.\n\n_Со стороны кожных покровов:_ очень редко -кожный зуд, гиперемия кожи, крапивница.\n\n_Общие:_ очень редко - общая слабость, лихорадка.\n\n##### ПЕРЕДОЗИРОВКА\n\nСлучаи передозировки неизвестны.\n\n_Симптомы:_ возможно усиление побочных эффектов.\n\n_Лечение:_ при приеме внутрь большого количества препарата необходимо сделать промывание желудка. Лечение симптоматическое. Специфического антидота нет.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nТиотриазолин® можно применять на фоне стандартной терапии гепатитов и стабильной стенокардии (нитраты, ингибиторы ангиотензинпревращающего фермента, b-адреноблокаторы, блокаторы «медленных» кальциевых каналов, антиагрегантные препараты, антагонисты рецепторов ангиотензина II, ингибиторы ГМГ-КоА редуктазы (статины)).\n\n##### ФОРМА ВЫПУСКА\n\nТаблетки 200 мг.\n\nПо 10 или 30 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной или пленки поливинилхлоридной Aclar® и фольги алюминиевой печатной лакированной.\n\nПо 60, 90, 100 или 120 таблеток в банки из полиэтилентерефталата для лекарственных средств или полипропиленовые для лекарственных средств, укупоренные крышками из полиэтилена высокого давления с контролем первого вскрытия или крышками полипропиленовыми с системой «нажать-повернуть», или крышками из полиэтилена низкого давления с контролем первого вскрытия.\n\nСвободное пространство в банке заполняют ватой медицинской гигроскопической.\n\nПо 60, 90, 100 или 120 таблеток во флаконы темного стекла, укупоренные полимерными с влагопоглотителем (силикагель 2,3 г) и контролем первого вскрытия.\n\nНа банку (флакон) наклеивают этикетку самоклеящуюся.\n\nОдну банку или флакон, или 2,3 ,5, 6 или 9 контурных ячейковых упаковок вместе с инструкцией по медицинскому применению помещают в картонную упаковку (пачку).\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\n**Не применять для купирования приступов стенокардии!**\n\nВ состав таблеток входит сахароза - 5,6 мг в одной таблетке, т.е. в максимальной суточной дозе (4 таблетки) содержится 22,4 мг сахарозы, что нужно учитывать пациентам с сахарным диабетом.\n\nПрименение препаратаТиотриазолин® у детей до 18 лет не рекомендуется (отсутствует опыт применения).\n\nПри применении у пациентов пожилого возраста (старше 65 лет), в силу возрастного снижения функции почек, необходим периодический контроль креатинина, мочевины.\n\n##### ВЛИЯНИЕ НА УПРАВЛЕНИЕ ТРАНСПОРТНЫМИ СРЕДСТВАМИ И МЕХАНИЗМАМИ\n\nВлияние препарата на способность к управлению автотранспортными средствами и работе с механизмами не изучалось. Однако, учитывая возможный риск развития головокружения, необходимо соблюдать осторожность при управлении автотранспортными средствами и работе с механизмами.\n\n##### СРОК ГОДНОСТИ\n\n2 года. Не применять препарат по истечении срока годности, указанного на упаковке.\n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nВ защищенном от света месте при температуре от 15 °С до 25 °С.\n\nХранить в недоступном для детей месте!\n\n##### УСЛОВИЯ ОТПУСКА\n\nПо рецепту\n\n##### ПРОИЗВОДИТЕЛЬ И ПРИНИМАЮЩИЙ ПРЕТЕНЗИИ\n\n**Производитель**\n\nООО «Озон»\n\nЮридический адрес: 445351, Россия, Самарская обл., г. Жигулевск, ул. Песочная, д. 11, Адрес производства, в том числе для переписки и приема претензий: 445351, Россия, Самарская обл., г. Жигулевск, ул. Гидростроителей, д. 6. Тел./факс: (84862) 3-41-09\n\nЕ-mail: оzon@оzon-рharm.ru www.ozonpharm.ru\n\n \n\n**Владелец регистрационного удостоверения/ Организация, принимающая претензии потребителей:**\n\nООО \"Арт-Фарм\"\n\nРоссия, 109147, г. Москва, ул. Таганская, 17-23, этаж 6\n\nТел./факс: 8-495-640-20-02; +7-967-054-36-98\n\nE-mail: Vladislavl.Gorbunov@art-pharm.ru\n\n##### СОСТАВ\n\nВ одной таблетке содержится:\n\n_действующее вещество:_ морфолиний-метил- триазолил-тиоацетат (тиотриазолин) 200 мг;\n\n_вспомогательные вещества:_ крахмал картофельный 16 мг, повидон низкомолекулярный 8 мг, сахароза 5,6 мг, целлюлоза микрокристаллическая 8 мг, кальция стеарат 2,4 мг.\n\n##### ПРОТИВОПОКАЗАНИЯ\n\nПовышенная чувствительность к морфолиний-метил-триазолил-тиоацетату и другим вспомогательным компонентам препарата; умеренные и тяжелые нарушения функции почек (клиренс креатинина (КК) < 60 мл/мин); детский возраст до 18 лет (эффективность и безопасность не установлены). Беременность и период грудного вскармливания.\n\nДефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная мальабсорбция.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1113],{"_1114":1115,"_274":1116},"details","Цена действительна только при заказе онлайн. 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Изображения

ТИОТРИАЗОЛИН ТАБ 200МГ №60

МНН / ГРУППИРОВОЧНОЕ НАИМЕНОВАНИЕ / ХИМИЧЕСКОЕ НАИМЕНОВАНИЕ