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Препятствует повреждающему действию свободных радикалов, сохраняет целостность клеточных мембран, предотвращает активацию нейтрофилов в зоне ишемии, увеличивает продолжительность электрического потенциала, уменьшает выход креатинфосфокиназы из клеток и выраженность ишемических повреждений миокарда.\n\nТриметазидин сокращает частоту приступов стенокардии (уменьшается потребление нитратов), через 2 недели применения препарата повышается толерантность к физической нагрузке, снижаются резкие колебания АД. Уменьшается головокружение и шум в ушах.\n\nПри сосудистой патологии глаз улучшает функциональную активность сетчатки глаза.\n\n##### ФАРМАКОКИНЕТИКА\n\n _Всасывание_\n\nПосле приема внутрь быстро и практически полностью абсорбируется из ЖКТ. Биодоступность составляет 90%. Cmax достигается через 5 ч.\n\n_Распределение_\n\nСвязывание с белками плазмы составляет 16%. Css достигается через 60 ч. Vd составляет 4.8 л/кг, что предполагает хорошее распределение в тканях. Легко проникает через гистогематические барьеры.\n\n_Выведение_\n\nВыводится почками, около 60% - в неизмененном виде. T1/2 составляет около 7 ч.\n\n_Фармакокинетика в особых клинических случаях_\n\nT1/2 у пациентов в возрасте старше 65 лет составляет около 12 ч.\n\nПочечный клиренс триметазидина прямо коррелирует с КК, печеночный клиренс снижается с возрастом.\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * ИБС: профилактика приступов стабильной стенокардии (в составе комплексной терапии);\n * хориоретинальные нарушения с ишемическим компонентом;\n * кохлео-вестибулярные нарушения ишемической природы (головокружение, шум в ушах, нарушения слуха).\n\n\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * почечная недостаточность тяжелой степени (КК <15 мл/мин);\n * выраженные нарушения функции печени;\n * беременность;\n * период лактации (грудного вскармливания);\n * детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены);\n * повышенная чувствительность к компонентам препарата.\n\n\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nПрепарат противопоказан при беременности из-за отсутствия клинических данных о безопасности его применения.\n\nНеизвестно, выделяется ли триметазидин с грудным молоком. При необходимости применения препарата в период лактации следует прекратить грудное вскармливание.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nПротивопоказание: детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены). \n\n##### ПРИМЕНЕНИЯ ПРИ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ\n\nПротивопоказан при выраженных нарушениях функции печени. \n\nПротивопоказан при почечной недостаточности тяжелой степени (КК<15 мл/мин). \n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nПрепарат принимают внутрь, во время еды.\n\nРекомендуемая доза - по 1 таб. 2 раза/сут (утром и вечером).\n\nПродолжительность лечения устанавливают индивидуально.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nЧастота побочных эффектов, отмеченных при приеме триметазидина, приведена в следующей градации: очень часто (>1/10); часто (>1/100, <1/10); нечасто (>1/1000, <1/100); редко (>1/10 000, <1/1000); очень редко (<1/10 000, в т.ч. отдельные сообщения).\n\n_Со стороны ЦНС:_ часто - головокружение, головная боль; очень редко - экстрапирамидные расстройства (тремор, ригидность, акинезия), обратимые после отмены препарата.\n\n_Со стороны сердечно-сосудистой системы:_ редко - ортостатическая гипотензия, \"приливы\" крови к коже лица.\n\n_Со стороны пищеварительной системы:_ часто - боль в животе, диарея, диспепсия, тошнота, рвота.\n\n_Аллергические реакции:_ часто - кожная сыпь, зуд, крапивница.\n\n_Прочие_ : часто - астения.\n\n##### ПЕРЕДОЗИРОВКА\n\nДанные о случаях передозировки ограничены.\n\n_Лечение:_ в случае передозировки следует проводить симптоматическую терапию.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nНет сведений о лекарственном взаимодействии препарата Депренорм® МВ.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nПрепарат не предназначен для купирования приступов стенокардии, для начального курса терапии стабильной стенокардии или инфаркта миокарда.\n\nПри развитии приступов стенокардии следует пересмотреть проводимую терапию.\n\n_Влияние на способность к управлению транспортными средствами и механизмами_\n\nПрименение препарата не влияет на способность к управлению транспортным средством и выполнению работ, требующих повышенной скорости психомоторных реакций.\n\n##### СРОК ГОДНОСТИ\n\nСрок годности - 3 года. \n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПрепарат следует хранить в недоступном для детей, сухом, защищенном от света месте при температуре не выше 25°С. \n\n##### УСЛОВИЯ ОТПУСКА\n\nПо рецепту\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * почечная недостаточность тяжелой степени (КК <15 мл/мин);\n * выраженные нарушения функции печени;\n * беременность;\n * период лактации (грудного вскармливания);\n * детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены);\n * повышенная чувствительность к компонентам препарата.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1169],{"_859":1170,"_274":1171},"Цена действительна только при заказе онлайн. 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ДЕПРЕНОРМ МВ ТАБ ПРОЛОНГ П/П/О 35МГ №60

ФАРМАКО-ТЕРАПЕВТИЧЕСКАЯ ГРУППА