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МНН / ГРУППИРОВОЧНОЕ НАИМЕНОВАНИЕ / ХИМИЧЕСКОЕ НАИМЕНОВАНИЕ\n\nЭрдостеин\n\n##### СОСТАВ\n\n _Каждая капсула содержит:_ \n_Действующее вещество:_ эрдостеин, 300,00 мг. \n_Вспомогательные вещества:_ целлюлоза микрокристаллическая (VIVAPUR®102) 10,00 мг, повидон К30 8,00 мг, магния стеарат 3,00 мг. \nСостав оболочки капсулы: желатин 74,4 мг, титана диоксид (E171) 0,76 мг, краситель железа оксид желтый (E172) 0,749 мг, краситель индигокармин (Е132) 0,091 мг. \n \n\n\n##### ОПИСАНИЕ\n\nТвердые желатиновые капсулы, имеющие корпус желтого цвета и крышечку зеленого цвета. Содержимое капсул: порошок от белого до почти белого цвета.\n\n##### ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА\n\n**Фармакотерапевтическая группа:** отхаркивающее муколитическое средство. \n**Код АТХ:** R05CB15 \n \n**Фармакологические свойства \n** \n_**Фармакодинамика**_ \nЭдомари является новым препаратом, эффективность которого обусловлена действием активных метаболитов. \nТиоловые группы метаболитов вызывают разрыв дисульфидных мостиков, которые связывают одно с другим волокна гликопротеинов, это приводит к уменьшению эластичности и вязкости мокроты. В результате, эрдостеин усиливает и ускоряет освобождение респираторных путей от секрета, улучшает секреторную функцию эпителия и увеличивает эффективность мукоцилиарного транспорта в верхних и нижних отделах респираторного тракта. \nЭрдостеин оказывает антиоксидантное действие и переносит свободные радикалы; в частности, эрдостеин защищает дыхательные пути от повреждающего действия сигаретного дыма в отношении инактивации альфа-1-антитрипсина. \nЭрдостеин увеличивает концентрацию IgA в слизистой оболочке дыхательных путей у больных с хроническими обструктивными заболеваниями дыхательных путей, а также снижает подавляющее действие табачного дыма на функции гранулоцитов. \nЭффект от терапии препаратом развивается на 3-4 сутки лечения. Эрдостеин как таковой не содержит свободные SH-радикалы. Поэтому препарат не оказывает повреждающего действия на желудочно-кишечный тракт, и побочные эффекты со стороны пищеварительной системы не отличаются от эффектов плацебо. \n \n_**Фармакокинетика**_ \nБыстро абсорбируется из желудочно-кишечного тракта и метаболизируется в печени до трех активных метаболитов, наиболее важный из которых – N-тиодигликолил-гомоцистеин (Метаболит 1 или М1). Период полувыведения (T1/2) более 5 часов. Повторное применение препарата или прием пищи не влияет на фармакокинетические параметры. Максимальная концентрация (Сmax) – 3,46 мкг/мл; время достижения максимальной концентрации (Tmax) – 1,48 ч; площадь под кривой «концентрация-время» (AUC (0 - 24 ч)) – 12.09. \n64,5 % эрдостеина связывается белками плазмы крови. Препарат выводится в виде неорганических сульфатов через почки и кишечник. \nВ случае нарушения функции печени отмечается увеличение показателей: максимальная концентрация (Сmax) и площадь под кривой «концентрация-время» (AUC). \nВозможно увеличение периода полувыведения (T1/2) при выраженном нарушении функции печени. При почечной недостаточности возможна кумуляция метаболитов. \n\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n• Заболевания дыхательных путей с образованием вязкой мокроты: \n– острый и хронический бронхит; \n– пневмония; \n– ХОБЛ; \n– бронхиальная астма с затруднением отхождения мокроты; \n– бронхоэктатическая болезнь. \n• Профилактика пневмонии и ателектаза легких после хирургических вмешательств. \n \n\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n• Гиперчувствительность к входящим в состав препарата ингредиентам. \n• Детский возраст до 18 лет. \n• Нарушение функции печени. \n• Почечная недостаточность (клиренс креатинина < 25 мл/мин). \n• Гомоцистеинурия (препарат является источником гомоцистеина, поэтому возможны нарушения метаболизма аминокислот у пациентов, находящихся на диете со сниженным содержанием свободного метионина). \n• Беременность I триместр, период грудного вскармливания. \n \n \n**С осторожностью** \n\\- При заболеваниях бронхов, сопровождающихся чрезмерным скоплением секрета. \n\\- При почечной недостаточности возможна кумуляция метаболитов. \n\\- При выраженном нарушении функции печени возможно увеличение периода полувыведения. \n \n\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nДоклинические исследования не выявили эмбриотоксического действия препарата ЭДОМАРИ. Однако опыт применения препарата в период беременности и грудного вскармливания ограничен. Поэтому назначение препарата возможно только во II и III триместрах беременности, если предполагаемая польза для матери превышает потенциальный риск для плода.\n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nПо 1 капсуле (300 мг) 2–3 раза в день. \nЕсли нет улучшения в течение 5 дней после начала применения препарата, или если наступит ухудшение, необходимо обратиться к лечащему врачу. \n \n\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nСо стороны желудочно-кишечного тракта \nРедко (от ≥ 1/10000 до < 1/1000): изжога. \nОчень редко (от < 1/10000): тошнота, рвота, боли в эпигастральной области, диарея, утрата или изменение вкусовой чувствительности. \n \nСо стороны кожи и подкожной ткани: \nОчень редко (от < 1/10000): реакции кожной гиперчувствительности, в том числе: эритема, отек и экзема. \nЧастота не известна: ангионевротический отек. \n \nНарушения со стороны дыхательной системы, грудной клетки и средостения: \nОчень редко (от < 1/10000): одышка. \n \n\n\n##### ПЕРЕДОЗИРОВКА\n\nО случаях передозировки препарата не сообщалось. Однако в случаях передозировки или при случайном применении детьми рекомендуются промывание желудка и проведение симптоматической терапии.\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nПри совместном применении эрдостеин увеличивает концентрацию амоксициллина в бронхиальном секрете, что позволяет добиться более быстрого ответа на терапию по сравнению с монотерапией амоксициллином.\n\n##### ФОРМА ВЫПУСКА\n\nКапсулы 300 мг. По 10 капсул в блистер из ПВХ/ПВДХ пленки и алюминиевой фольги. 1 или 2 блистера вместе с инструкцией по применению помещают в пачку картонную.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nПри лечении необходимо принимать достаточное количество жидкости, что повышает отхаркивающий эффект. В случаях нарушения моторики бронхов или при значительном объеме выделяемой мокроты (например, при синдроме неподвижных ресничек (Синдром Картагенера)) применение препарата требует осторожности в связи с риском задержки отделяемого в дыхательных путях и увеличением риска присоединения инфекции или бронхоспазма. \n \n**Влияние на способность управлять транспортными средствами, механизмами** \nПрименение препарата не оказывает влияния на способность управлять автотранспортом и иную деятельность, требующую повышенного внимания. \n \n\n\n##### СРОК ГОДНОСТИ\n\n5 лет \nНе использовать по истечении срока годности, указанного на упаковке. \n \n\n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nХранить при температуре не выше 25° С. Хранить в недоступном для детей месте!\n\n##### УСЛОВИЯ ОТПУСКА\n\nОтпускают без рецепта\n\n##### ПРОИЗВОДИТЕЛЬ И ПРИНИМАЮЩИЙ ПРЕТЕНЗИИ\n\nЭдмонд Фарма С.р.л., Италия\n\n##### СОСТАВ\n\n _Каждая капсула содержит:_ \n_Действующее вещество:_ эрдостеин, 300,00 мг. \n_Вспомогательные вещества:_ целлюлоза микрокристаллическая (VIVAPUR®102) 10,00 мг, повидон К30 8,00 мг, магния стеарат 3,00 мг. \nСостав оболочки капсулы: желатин 74,4 мг, титана диоксид (E171) 0,76 мг, краситель железа оксид желтый (E172) 0,749 мг, краситель индигокармин (Е132) 0,091 мг. \n \n\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n• Гиперчувствительность к входящим в состав препарата ингредиентам. \n• Детский возраст до 18 лет. \n• Нарушение функции печени. \n• Почечная недостаточность (клиренс креатинина < 25 мл/мин). \n• Гомоцистеинурия (препарат является источником гомоцистеина, поэтому возможны нарушения метаболизма аминокислот у пациентов, находящихся на диете со сниженным содержанием свободного метионина). \n• Беременность I триместр, период грудного вскармливания. \n \n \n**С осторожностью** \n\\- При заболеваниях бронхов, сопровождающихся чрезмерным скоплением секрета. \n\\- При почечной недостаточности возможна кумуляция метаболитов. \n\\- При выраженном нарушении функции печени возможно увеличение периода полувыведения.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1107],{"_1108":1109,"_274":1110},"details","Цена действительна только при заказе онлайн. 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ЭДОМАРИ КАПС 300МГ №20

МНН / ГРУППИРОВОЧНОЕ НАИМЕНОВАНИЕ / ХИМИЧЕСКОЕ НАИМЕНОВАНИЕ