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Является первичным активным метаболитом лоратадина. Подавляет высвобождение гистамина из тучных клеток. Ингибирует каскад реакций аллергического воспаления, в т.ч. высвобождение провоспалительных цитокинов, включая интерлейкины ИЛ-4, ИЛ-6, ИЛ-8, ИЛ-13, выделение молекул адгезии, таких как Р-селектин. Таким образом, предупреждает развитие и облегчает течение аллергических реакций, обладает противозудным и антиэкссудативным действием, уменьшает проницаемость капилляров, предупреждает развитие отека тканей, спазма гладкой мускулатуры.\n\nПрепарат не оказывает воздействия на ЦНС, практически не обладает седативным эффектом (не вызывает сонливости) и не влияет на скорость психомоторных реакций. В клинико-фармакологических исследованиях применения дезлоратадина в рекомендуемой терапевтической дозе не отмечалось удлинения интервала QT нa ЭКГ.\n\nДействие препарата Эриус® начинается в течение 30 мин после приема внутрь и продолжается в течение 24 ч.\n\n##### ФАРМАКОКИНЕТИКА\n\n _Всасывание_\n\nПосле приема препарата внутрь дезлоратадин хорошо всасывается из ЖКТ. Определяется в плазме крови через 30 минут после приема внутрь. Cmax достигается в среднем через 3 ч после приема. \n\n_Распределение_\n\nСвязывание дезлоратадина с белками плазмы составляет 83-87%. При применении у взрослых и подростков в течение 14 дней в дозе от 5 мг до 20 мг 1 раз/сут признаков клинически значимой кумуляции дезлоратадина не выявлено. Одновременный прием пищи или одновременное употребление грейпфрутового сока не влияет на распределение дезлоратадина (при приеме в дозе 7.5 мг 1 раз/сут). Не проникает через ГЭБ.\n\n_Метаболизм_\n\nИнтенсивно метаболизируется путем гидроксилирования с образованием 3-ОН-дезлоратадина, соединенного с глюкуронидом. Дезлоратадин не является ингибитором CYP3A4 и CYP2D6 и не является субстратом или ингибитором Р-гликопротеина. \n\n_Выведение_\n\nЛишь небольшая часть принятой внутрь дозы выводится почками (<2%) и через кишечник (<7%) в неизмененном виде.\n\nT1/2 \\- в среднем 27 ч.\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\n * аллергический ринит (устранение или облегчение чиханья, заложенности носа, выделения слизи из носа, зуда в носу, зуда неба, зуда и покраснения глаз, слезотечения);\n * крапивница (уменьшение или устранение кожного зуда, сыпи).\n\n\n\n##### МКБ-10\n\nКод МКБ-10| Показание \n---|--- \nJ30.1| Аллергический ринит, вызванный пыльцой растений \nJ30.3| Другие аллергические риниты (круглогодичный аллергический ринит) \nL29| Зуд \nL50| Крапивница \n \n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к дезлоратадину, другим компонентам препарата или лоратадину;\n * беременность;\n * период грудного вскармливания;\n * детский возраст до 6 месяцев;\n * наследственно передаваемые заболевания (непереносимость фруктозы, нарушение всасывания глюкозы/галактозы или недостаточность сахаразы/изомальтазы в организме) в связи с наличием сахарозы и сорбитола в составе сиропа.\n\n\n\n_С осторожностью_\n\nТяжелая почечная недостаточность. \n\nСудороги в анамнезе.\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nНазначение препарата Эриус® при беременности не рекомендуется в связи с отсутствием клинических данных о безопасности его применения в данный период.\n\nДезлоратадин выделяется с грудным молоком, поэтому применение препарата Эриус® в период грудного вскармливания не рекомендуется.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nЭффективность и безопасность применения препарата Эриус® в форме сиропа у **детей в возрасте до 6 месяцев** не установлена, применение у данной категории пациентов противопоказано.\n\n##### ПРИМЕНЕНИЯ ПРИ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ\n\nС осторожностью следует применять препарат при почечной недостаточности тяжелой степени. \n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nВнутрь, независимо от приема пищи, запивая небольшим количеством воды.\n\n**Детям в возрасте от 6 до 12 месяцев -** по 1 мг (2 мл сиропа) 1 раз/сут.\n\n**Детям в возрасте от 1 года до 5 лет** \\- по 1.25 мг (2.5 мл сиропа) 1 раз/сут.\n\n**Детям в возрасте от 6 до 11 лет** \\- по 2.5 мг (5 мл сиропа) 1 раз/сут.\n\n**Взрослым и подросткам от 12 лет** \\- по 5 мг (10 мл сиропа) 1 раз/сут.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\nУ **детей в возрасте от 6 до 23 месяцев** отмечались следующие побочные эффекты, частота которых была несколько выше, чем при применении плацебо: диарея (3.7%), повышение температуры тела (2.3%), бессонница (2.3%).\n\nУ **детей в возрасте от 2 до 11 лет** при применении препарата Эриус® сироп частота побочных эффектов была такой же, как при применении плацебо.\n\nПо результатам клинических исследований у **детей в возрасте от 6 до 11 лет** при приеме препарата в рекомендуемых дозах (2.5 мг/сут) побочных эффектов не выявлено.\n\nУ **детей в возрасте 12-17 лет** по результатам клинических исследований, наиболее часто встречающийся побочный эффект - являлась головная боль (5.9%), частота которой была не выше, чем при приеме плацебо (6.9%). \n\nУ **взрослых и подростков в возрасте 12 лет и старше** по результатам клинических исследований побочные эффекты были зафиксированы у 3% пациентов по сравнению с группой, применявших плацебо, из них чаще всего отмечались повышенная утомляемость (1.2%), сухость во рту (0.8%), головная боль (0.6%).\n\nПри применении препарата Эриус® у взрослых и подростков в рекомендуемой дозе 5 мг/сут частота возникновения сонливости была не выше, чем при применении плацебо.\n\nИнформация о побочных эффектах представлена по результатам клинических исследований и наблюдений пострегистрационного периода.\n\nПо данным ВОЗ побочные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥1/10), часто (от ≥1/100 до <1/10), нечасто (от ≥1/1000 до <1/100), редко (от ≥1/10 000 до <1/1000), очень редко (<1/10 000), частота неизвестна (по имеющимся данным установить частоту возникновения не представлялось возможным).\n\n_Со стороны психики:_ очень редко - галлюцинации; частота неизвестна - аномальное поведение, агрессия.\n\n_Со стороны нервной системы:_ часто - головная боль, у детей до 2 лет - бессонница; очень редко - головокружение, сонливость, бессонница, психомоторная гиперактивность, судороги.\n\n_Со стороны печени и желчевыводящих путей:_ очень редко - повышение активности ферментов печени, повышение концентрации билирубина, гепатит; частота неизвестна - желтуха.\n\n_Со стороны пищеварительной системы:_ часто - сухость во рту, у детей до 2 лет - диарея; очень редко - боль в животе, тошнота, рвота, диспепсия, диарея, повышение аппетита.\n\n_Со стороны сердечно-сосудистой системы:_ очень редко - тахикардия, сердцебиение; частота неизвестна - удлинение интервала QT.\n\n_Со стороны костно-мышечной системы:_ очень редко - миалгия.\n\n_Со стороны кожи и подкожных тканей:_ частота неизвестна - фотосенсибилизация.\n\n_Общие расстройства:_ часто - повышенная утомляемость, у детей до 2 лет - лихорадка; очень редко - анафилаксия, ангионевротический отек, одышка, зуд, сыпь, в т.ч. крапивница; частота неизвестна - астения.\n\n_Лабораторные и инструментальные данные:_ повышение массы тела. \n\n_Пострегистрационный период_\n\n**Дети:** частота неизвестна - удлинение интервала QT, аритмия, брадикардия, аномальное поведение, агрессия.\n\nЕсли любые из указанных выше побочных эффектов усугубляются, или пациент заметил любые другие побочные эффекты, следует сообщить об этом врачу.\n\n##### ПЕРЕДОЗИРОВКА\n\n _Симптомы:_ прием дозы, превышающей рекомендованную в 5 раз, не приводил к появлению каких-либо симптомов.\n\nВ ходе клинических исследований ежедневное применение у взрослых и подростков дезлоратадина в дозе до 20 мг в течение 14 дней не сопровождалось статистически или клинически значимыми изменениями со стороны сердечно-сосудистой системы. В клинико-фармакологическом исследовании применение дезлоратадина в дозе 45 мг/сут (в 9 раз выше рекомендуемой) в течение 10 дней не вызывало удлинения интервала QT и не сопровождалось появлением серьезных побочных эффектов.\n\n_Лечение:_ при случайном приеме внутрь большого количества препарата пациент должен незамедлительно обратиться к врачу. Проводится промывание желудка, прием активированного угля; при необходимости - симптоматическая терапия. Дезлоратадин не выводится при гемодиализе, эффективность перитонеального диализа не установлена. \n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nВ исследованиях не выявлено взаимодействия с азитромицином, кетоконазолом, эритромицином, флуоксетином и циметидином.\n\nПрием пищи не оказывает влияния на эффективность препарата.\n\nЭриус® не усиливает действия этанола на ЦНС. Тем не менее, во время пострегистрационного применения были зарегистрированы случаи непереносимости алкоголя и алкогольного опьянения, поэтому дезлоратадин одновременно с алкоголем следует применять с осторожностью.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nИсследований эффективности препарата Эриус® при ринитах инфекционной этиологии не проводилось.\n\nНеобходимо соблюдать осторожность при применении препарата Эриус® у пациентов с судорогами в анамнезе, особенно у **пациентов детского возраста**. Следует прекратить применение препарата в случае развития судорог.\n\n_Использование в педиатрии_\n\nЭффективность и безопасность препарата Эриус® в форме сиропа у **детей в возрасте до 6 месяцев** не установлена.\n\n_Влияние на способность к управлению транспортными средствами и механизмами_\n\nСледует принимать во внимание потенциальную возможность развития таких побочных эффектов, как головокружение и сонливость. При появлении описанных нежелательных явлений следует воздержаться от выполнения указанных видов деятельности.\n\n##### СРОК ГОДНОСТИ\n\nСрок годности - 2 года. \n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПрепарат следует хранить в недоступном для детей месте при температуре не выше 30°С. \n\n##### УСЛОВИЯ ОТПУСКА\n\nОтпускают без рецепта\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к дезлоратадину, другим компонентам препарата или лоратадину;\n * беременность;\n * период грудного вскармливания;\n * детский возраст до 6 месяцев;\n * наследственно передаваемые заболевания (непереносимость фруктозы, нарушение всасывания глюкозы/галактозы или недостаточность сахаразы/изомальтазы в организме) в связи с наличием сахарозы и сорбитола в составе сиропа.\n\n\n\n_С осторожностью_\n\nТяжелая почечная недостаточность. \n\nСудороги в анамнезе.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1161],{"_858":1162,"_274":1163},"Цена действительна только при заказе онлайн. 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ЭРИУС СИРОП 0,5МГ/МЛ 60МЛ

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