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Карбоангидраза - это фермент, присутствующий во многих тканях организма, включая ткани глаза. Катализирует обратимые реакции, в которых происходит гидратация двуокиси углерода и гидролиз угольной кислоты. У человека карбоангидраза присутствует в виде ряда изоферментов, самый активный из них - карбоангидраза II (КА-II), обнаруживаемая, прежде всего, в эритроцитах и в других тканях. Ингибирование карбоангидразы II в цилиарном теле глаза уменьшает продукцию внутриглазной жидкости вследствие замедления образования ионов бикарбоната с последующим снижением транспорта натрия и жидкости. В результате происходит снижение внутриглазного давления.\n\n##### ФАРМАКОКИНЕТИКА\n\n _Всасывание_\n\nПри местном применении бринзоламид всасывается в системный кровоток.\n\n_Распределение_\n\nСвязывание с белками плазмы составляет 60%.\n\n_Метаболизм_\n\nБринзоламид абсорбируется в эритроцитах за счет избирательного связывания с карбоангидразой II.\n\nМетаболизируется с образованием N-дезэтилбринзоламида, который связывается с карбоангидразой (в основном с карбоангидразой-I) и также накапливается в эритроцитах.\n\nПоскольку бринзоламид и его метаболит накапливаются в эритроцитах, их концентрация в плазме крови ниже предела количественного определения (<10 нг/мл).\n\n_Выведение_\n\nT1/2 составляет 111 дней. Бринзоламид выводится с мочой в неизмененном виде и в виде метаболитов - основного (N-дезэтилбринзоламид) и небольших концентраций других метаболитов (N-дезметоксипропил и О-десметил).\n\n##### ПОКАЗАНИЯ К ПРИМЕНЕНИЮ\n\nДля снижения повышенного внутриглазного давления при:\n\n * открытоугольной глаукоме;\n * глазной гипертензии.\n\n\n\n##### МКБ-10\n\nКод МКБ-10| Показание \n---|--- \nH40.0| Подозрение на глаукому (глазная гипертензия) \nH40.1| Первичная открытоугольная глаукома \nH40.3| Глаукома вторичная посттравматическая \nH40.4| Глаукома вторичная вследствие воспалительного заболевания глаза \nH40.5| Глаукома вторичная вследствие других болезней глаза \n \n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к компонентам препарата.\n\n\n\n##### ПРИМЕНЕНИЕ ПРИ БЕРЕМЕННОСТИ И КОРМЛЕНИИ ГРУДЬЮ\n\nАдекватных и строго контролируемых клинических исследований безопасности применения Азопта у беременных женщин не проводилось. Поэтому применение препарата Азопт при беременности возможно только в том случае, когда предполагаемая польза для матери превышает потенциальный риск для плода.\n\nНеизвестно, выделяется ли бринзоламид с грудным молоком. Поэтому при необходимости назначения Азопта в период лактации следует решить вопрос о прекращении грудного вскармливания.\n\n##### ПРИМЕНЕНИЕ ДЕТЬМИ\n\nЭффективность и безопасность применения препарата Азопт у детей не установлена. \n\n##### ПРИМЕНЕНИЯ ПРИ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ\n\nС осторожностью следует назначать Азопт при тяжелых нарушениях функции печени.\n\nПоскольку Азопт и его метаболиты выводятся с мочой, препарат не рекомендуется назначать пациентам с выраженными нарушениями функции почек (КК<30 мл/мин). \n\n##### СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ\n\nПрепарат закапывают по 1 капле в конъюнктивальный мешок пораженного глаза (или глаз) 2 раза/сут. \n\nПеред применением препарата флакон следует встряхнуть.\n\n##### ПОБОЧНОЕ ДЕЙСТВИЕ\n\n _Со стороны органа зрения:_ 5-10% - затуманивание зрения; 1-5% - блефарит, кератит, сухость глаз, гиперемия, ощущение инородного тела в глазу, выделения из глаз, дискомфорт, боль, зуд глаз; <1% - конъюнктивит, кератоконъюнктивит, кератопатия, начальные симптомы блефарита (слипание век или корочки на краях век), слезотечение, диплопия, астенопия.\n\n_Со стороны пищеварительной системы:_ 5-10% - горький, кислый или необычный вкус во рту; <1% - сухость во рту, диспепсия, тошнота, диарея.\n\n_Со стороны дыхательной системы:_ 1-5% - ринит; <1% - одышка, фарингит.\n\n_Со стороны сердечно-сосудистой системы:_ <1% - боль в груди, гипертензия.\n\n_Со стороны мочевыделительной системы:_ <1% - боль в почках.\n\n_Аллергические реакции:_ <1% - крапивница.\n\n_Прочие:_ 1-5% - головная боль, дерматит; <1% - алопеция, головокружение.\n\n##### ПЕРЕДОЗИРОВКА\n\nДанных о передозировке при местном применении Азопта нет.\n\nПри передозировке, вызванной случайным приемом препарата внутрь, могут возникнуть следующие _симптомы:_ нарушение электролитного баланса, ацидоз, нарушения со стороны нервной системы.\n\n_Лечение:_ при необходимости проводят симптоматическую терапию; также необходимо контролировать рН крови, уровень электролитов (особенно калия).\n\n##### ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ И ДРУГИЕ ВИДЫ ВЗАИМОДЕЙСТВИЯ\n\nПри одновременном применении Азопта и ингибиторов карбоангидразы для системного применения возможно усиление системных реакций, связанных с угнетением фермента. Поэтому не рекомендуется назначать такую комбинацию.\n\nПри одновременном применении Азопта и салицилатов в высоких дозах возможны нарушения кислотно-щелочного и электролитного баланса.\n\n##### ОСОБЫЕ УКАЗАНИЯ\n\nС осторожностью следует назначать Азопт при тяжелых нарушениях функции печени.\n\nПоскольку Азопт и его метаболиты выводятся с мочой, препарат не рекомендуется назначать пациентам с выраженными нарушениями функции почек (КК<30 мл/мин).\n\nСледует учитывать, что бринзоламид является сульфаниламидом. Так как при местном применении происходит его системная абсорбция, возможно развитие побочных реакций, в т.ч. тяжелых аллергических реакций (таких как синдром Стивенса-Джонсона, токсический эпидермальный некролиз, гепатонекроз, агранулоцитоз, апластическая анемия). Сенсибилизация организма сульфаниламидами может развиться в том случае, если препарат назначается повторно с нарушениями указаний по его применению. При развитии тяжелых побочных реакций применение препарата следует прекратить.\n\nСледует учитывать, что входящий в состав препарата Азопт бензалкония хлорид может накапливаться в контактных линзах, поэтому линзы следует снять перед закапыванием и установить обратно не раньше чем через 15 мин после применения препарата.\n\nПри применении нескольких лекарственных средств интервал между закапыванием должен составлять не менее 15 мин. \nНе следует прикасаться к глазу кончиком капельницы флакона.\n\n_Использование в педиатрии_\n\nЭффективность и безопасность применения препарата Азопт у детей не установлена.\n\n_Влияние на способность к управлению транспортными средствами и механизмами_\n\nСразу после применения Азопта может временно возникнуть затуманивание зрения. Поэтому пациенту следует соблюдать осторожность при вождении транспортных средств и при работе с техникой.\n\n##### СРОК ГОДНОСТИ\n\nСрок годности - 2 года.\n\nПосле вскрытия флакона препарат следует использовать в течение 4 недель.\n\n##### УСЛОВИЯ ХРАНЕНИЯ\n\nПрепарат следует хранить при температуре от 4° до 30°С в местах, недоступных для детей. \n\n##### УСЛОВИЯ ОТПУСКА\n\nПо рецепту\n\n##### ПРОТИВОПОКАЗАНИЯ\n\n * повышенная чувствительность к компонентам препарата.","overSized","imageComparisonOptions",[],"reviewsCounters",{},"redemptionStats",[],"saleEndsDateIso","cashback","showMultipleFractionsCounter","promoTitle","promoDescription","promoLegalDescription","lowestRecentPrice","productDisclaimers",[1114],{"_1115":1116,"_274":1117},"details","Цена действительна только при заказе онлайн. Внешний вид товара может отличаться от изображённого на фотографии","Обратите внимание","otherColors","colorCode","guid","dataUpdateCount","dataUpdatedAt","error","errorUpdateCount","errorUpdatedAt","fetchFailureCount","fetchFailureReason","fetchMeta","isInvalidated","status","success","fetchStatus","idle","queryKey",[1136,1137],"items",{"_996":98,"_1138":1139,"_313":1142},"body",{"_1140":1141},"ids",[892],{"_1143":327,"_1144":327,"_1145":449,"_1146":449,"_900":445,"_1147":396,"_1148":249},"l[region]","l[city]","l[cityFiasId]","l[regionFiasId]","warehouseIds","deliveryId","queryHash","[\"items\",{\"body\":{\"ids\":[\"ffe37f1f-bab5-5007-92e2-60cc1061fbe9\"]},\"full\":true,\"params\":{\"country\":\"RU\",\"deliveryId\":\"1\",\"l[cityFiasId]\":\"0c5b2444-70a0-4932-980c-b4dc0d3f02b5\",\"l[city]\":\"Москва\",\"l[regionFiasId]\":\"0c5b2444-70a0-4932-980c-b4dc0d3f02b5\",\"l[region]\":\"Москва\",\"warehouseIds\":\"\"}}]","meta",{"_274":971,"_248":-7,"_621":-7,"_624":-7,"_620":-7,"_1153":1154},"schemas",[1155],{"_17":1156,"_543":1157},"product",{"_1158":1159,"_1160":1161,"_1162":1163,"_962":971,"_276":1164,"_973":1050,"_1165":1024,"_1166":1021,"_1167":1168},"@context","https://schema.org","@type","Product","@id","https://aptekafarmat.ru/catalog/products/ffe37f1f-bab5-5007-92e2-60cc1061fbe9#product","https://aptekafarmat.ru/catalog/products/ffe37f1f-bab5-5007-92e2-60cc1061fbe9","sku","gtin","offers",[1169],{"_1160":1170,"_1162":1171,"_962":971,"_976":1172,"_637":979,"_1173":1174,"_1175":1176,"_1165":1024,"_1166":1021,"_276":1177,"_1178":1179},"Offer","https://aptekafarmat.ru/catalog/products/ffe37f1f-bab5-5007-92e2-60cc1061fbe9?variant=41571#offer","https://schema.org/InStock","priceCurrency","RUB","itemCondition","https://schema.org/NewCondition","https://aptekafarmat.ru/catalog/products/ffe37f1f-bab5-5007-92e2-60cc1061fbe9?variant=41571","seller",{"_1160":1180,"_1162":1181,"_962":610},"Organization","https://aptekafarmat.ru#organization","actionData","errors"]

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АЗОПТ КАПЛИ ГЛАЗНЫЕ 1% 5МЛ ФЛ-КАП.ПЛАСТИКОВЫЙ

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